Salmonellae were isolated from five (0·8 per cent) of 605 apparently healthy slaughter cattle. Two outbreaks of calf diarrhoea yielded Salmonellae which were pathogenic for mice. The four serotypes isolated (S. stanleyville, S. dublin, S. volksmarsdorf and N. njala) had not previously been found in Sierra Leone, and S. njala is entirely new. The possible connection between husbandry practice, infectivity and clinical disease is discussed. There is a need for a broader based and exhaustive study to elucidate the complex relationships of salmonellosis in animals for human consumption in Sierra Leone.