Yield (dry matter and grain yield) and macronutrients uptake of maize (Zea mays L.) subjected to irrigation with different proportions of pond water and sewage effluent were determined on an Alfisol. Changes in the amounts of nutrients in the soil were also determined. The proportion of the sewage effluent in the mix ranged from 0% to 100% with the 0% mix (pure pond water) serving as the control. Results showed that grain yield was higher while dry matter was lower in all the treatments with waste water than with pure pond water. The levels of the macronutrients were generally within reasonable limits and compared favourably with levels in some common crops for the treatments. Maximum uptakes of N and K occurred at the highest sewage dose while maximum uptake of P occurred at the least sewage dose. The 50:50 mix ratio compared best with the control in terms of nutrient uptake and soil salinity. Analysis of the soil showed that much of the N was lost, most of the K was fixed in non-assimilable form, and most of the P was available to the plants. Most of the micronutrients from the wastes were immobilized in the soil, probably because of organic matter in the soil. When the results of the 50:50 mix and the control were compared, the sewage resulted in higher K, Mg, Ca, P, and Mn in the soil.